Search results for "model [interaction]"
showing 10 items of 1495 documents
Lack of genetic association of neutral endopeptidase (NEP) with complex regional pain syndrome (CRPS)
2010
Complex regional pain syndrome (CRPS) is a condition that is characterized by severe pain and exaggerated neurogenic inflammation, which may develop after injury or surgery. Neurogenic inflammation is mediated by neuropeptides, such as calcitonin gene-related peptide (CGRP) and substance P (SP) that are released from nociceptors. Genetic factors may play a role in CRPS as was suggested by the occurrence of familial cases and several genetic association studies investigating mainly the human leukocyte antigen (HLA) system. Here we investigated the role of neutral endopeptidase (NEP), a key enzyme in neuropeptide catabolism. NEP dysfunction resulting in reduced inactivation of neuropeptides m…
Key issues in decomposing fMRI during naturalistic and continuous music experience with independent component analysis
2014
Background: Independent component analysis (ICA) has been often used to decompose fMRI data mostly for the resting-state, block and event-related designs due to its outstanding advantage. For fMRI data during free-listening experiences, only a few exploratory studies applied ICA.New method: For processing the fMRI data elicited by 512-s modern tango, a FFT based band-pass filter was used to further pre-process the fMRI data to remove sources of no interest and noise. Then, a fast model order selection method was applied to estimate the number of sources. Next, both individual ICA and group ICA were performed. Subsequently, ICA components whose temporal courses were significantly correlated …
Evaluation of the antiproliferative, proapoptotic, and antiangiogenic effects of a double-stranded RNA mimic complexed with polycations in an experim…
2015
Objective To assess the antiproliferative, proapoptotic, and antiangiogenic effects of the double-stranded RNA mimic polyinosine-polycytidylic acid (pIC) complexed with polyethylenimine [pIC PEI ] in xenografted human leiomyomas. Design Heterologous leiomyoma mouse model. Setting University-affiliated infertility center. Animal(s) Ovariectomized and hormone-replaced nude mice (n = 16) who received human leiomyoma fragment transplantation. Intervention(s) Leiomyoma fragments placed in the peritoneum of 5-week-old nude female mice and treated with the vehicle (n = 8) or 0.6 mg/kg [pIC PEI ] (n = 8) for 4 weeks. Main Outcome Measure(s) The size of the leiomyoma implants, and cellular prolifera…
Improving ovarian tissue cryopreservation for oncologic patients: slow freezing versus vitrification, effect of different procedures and devices.
2013
Objective To compare slow freezing (SF) with four vitrification techniques (VT) for cryopreservation of ovarian tissue (OT) and to evaluate the best protocol for human OT in a xenograft model. Design Experimental study. Setting University hospital. Patient(s) Patients undergoing fertility preservation. Animal(s) Ovariectomized nude mice. Intervention(s) Cryopreservation of bovine OT after SF and four VTs (VT1, VT2, VT3, and VT4) by combining two cryoprotectant vitrification solutions (VS1 and VS2) and two devices (metallic grid and ethyl vinyl acetate bag), after which the cryopreservation of human OT by SF and VT1 and xenograft into nude mice. Main Outcome Measure(s) Follicular densities, …
Calorie Restriction in Mammals and Simple Model Organisms
2014
Calorie restriction (CR), which usually refers to a 20–40% reduction in calorie intake, can effectively prolong lifespan preventing most age-associated diseases in several species. However, recent data from both human and nonhumans point to the ratio of macronutrients rather than the caloric intake as a major regulator of both lifespan and health-span. In addition, specific components of the diet have recently been identified as regulators of some age-associated intracellular signaling pathways in simple model systems. The comprehension of the mechanisms underpinning these findings is crucial since it may increase the beneficial effects of calorie restriction making it accessible to a broad…
Personality and the gender wage gap
2012
In this study, we investigate whether personality traits contribute towards a better understanding of the reasons for the gender wage gap. We explore whether two of the personality factors put forward by Bowles et al. (2001) as likely to be incentive enhancing in the employer–employee relationship can explain the difference in wages for women and men. These are (1) personal self efficacy (Locus of Control (LoC)) and (2) time preference. We also study the role of the so called Big Five personality traits (extraversion, emotional stability, agreeableness, openness intellect and conscientiousness), which have been associated with earnings in several recent studies. Using a sample of Dutch empl…
Predictors of volitional personality change in younger and older adults: Response surface analyses signify the complementary perspectives of the self…
2017
Abstract Goals to change personality traits have been linked to self-rated Big Five traits. Extending previous research, we investigated the associations between change goals and diverse personality characteristics (e.g., self-esteem), other-rated Big Five traits, and self-other agreement in an age-heterogeneous sample ( N = 378). Results replicated previous associations of change goals with age and self-rated traits. Additionally, change goals were stronger when others rated a person’s traits as low and when self-other agreement about traits was greater for extraversion, agreeableness, and conscientiousness. Associations of additional personality characteristics with change goals diminish…
Personality profiles and health: Longitudinal evidence among Finnish adults
2012
Kinnunen, M.-L., Metsapelto, R. L., Feldt, T., Kokko, K., Tolvanen, A., Kinnunen, U., Leppanen, E. & Pulkkinen, L. (2012). Personality profiles and health: Longitudinal evidence among Finnish adults. Scandinavian Journal of Psychology 53, 512–522. This study investigates the associations of longitudinal Big Five personality profiles with long-term health in 304 adults (53% males). Personality traits (Neuroticism, Extraversion, Openness, Conscientiousness, Agreeableness) were assessed at ages 33, 42, and 50. Subjective (self-rated health, symptoms, psychological distress) and objective (body mass index, waist-to-hip ratio, blood pressure, cholesterol, triglycerides) indicators of health were…
Integration of personality constructs: The role of traits and motivation in the willingness to exert effort in academic and social life domains
2014
There has been growing interest in recent years in exploring different types of personality constructs and the nature of inter-relationships between personality variables in predicting outcomes in different life domains. The present study explores how personality traits and autonomous goal motivation predict the willingness to invest effort in academic and social life domains. Using a sample of 4133 upper secondary school students in Germany, multilevel regression analyses yielded three main results. First, both personality traits and motivation were substantially related to the willingness to exert effort. Second, the mediation effect compared to the direct effect was relatively small. Thi…
Examining Mechanisms of Personality Maturation
2012
Individuals are expected to mature with increasing age, but it is not yet fully understood which factors contribute to this maturation process. Using data of a representative sample of Germans ( N = 14,718) who gave information about their Big Five personality traits twice over a period of 4 years, the authors identified satisfaction with life, which was reported yearly, as an important variable for explaining mechanisms and interindividual differences in personality maturation. Dual latent change models suggest that more satisfied (compared to less satisfied) individuals experience more positive changes in Emotional Stability, Agreeableness, and Conscientiousness and that positive changes…